Purchase GoTrim 30-Day Jump-Start Kit

GoTrim 30-Day Jump-Start Kit

$199.00
with $3.98 (2%) Cashback
Includes NutriClean 7-Day Cleansing System; TLS CORE; Isotonix Daily Essentials Packets; 2 Nutrition Shakes – 1 Vanilla & 1 Chocolate; Jump-Start Booklet; Tracking Sheet

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Primary Benefits* of 30-Day Jump-Start Kit

NutriClean® 7-Day Cleansing System*

  • Helps maintain digestive health
  • Promotes liver and colon health
  • Supports overall health by helping to maintain normal cholesterol levels, helping to maintain normal blood glucose levels and promoting immune health
  • Assists with healthy nutrient absorption
  • Helps to cleanse and detoxify the liver

Nutrition Shake – Chocolate & Vanilla

  • 19 grams of protein and 10 grams of fiber per serving
  • Optimal balance of carbohydrates, fats and protein
  • Great taste
  • High in calcium
  • No trans fats

TLS CORE; Fat & Carb Inhibitor*

  • Helps promote weight loss
  • Supports leptin sensitivity, which may help to manage hunger and stimulate lipolysis
  • May help to reduce fat stores in the body
  • Promotes reduction in body mass index (BMI)
  • Inhibits the amylase enzyme and slows the absorption of carbohydrates into the bloodstream
  • Helps maintain normal blood sugar levels

Isotonix® Daily Essential Packets

Isotonix OPC-3® *

  • Promotes cardiovascular health PLUS:
    • Helps maintain healthy cholesterol & blood glucose levels
    • Helps maintain healthy circulation by strengthening capillaries, arteries and veins
    • Promotes healthy blood vessel dilation
  • Promotes joint health

Isotonix® Multivitamin*

  • Contains 100% or more of the Recommended Daily Value of essential vitamins & minerals
  • Supports a strong immune system
  • Supplements dietary deficiencies

Isotonix® Calcium Plus*

  • Supports skeletal health
  • Promotes normal regulation of enzyme & hormone production
  • Supports cardiovascular health

Isotonix Activated B-Complex*

  • Increases energy & fuels optimal energy production
  • Promotes a healthy nervous system, bone marrow & intestinal tract
  • Promotes cardiovascular health
  • Maintains healthy levels of serotonin, thereby decreasing stress & improving mood


*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.


Gluten-Free
Gluten-Free
Quality Statement (GMP)
Quality Statement (GMP)

 

What Makes the 30-Day Jump-Start Kit Unique?

These days, weight loss is depicted as a battle with complex programs, extreme exercise classes, highly restrictive diets and expensive gadgets. We believe weight loss should be simple. Our lives are stressful enough without adding in complicated weight loss regimes — getting healthy should be straightforward and achievable for everyone. Which is why we’ve developed the 30-Day Jump-Start Kit, designed to make getting back on track to health and wellness a cinch.

Inside the 30-Day Jump-Start Kit you’ll find the 30-Day Booklet and a Tracking Sheet, because weight loss is a journey and you need a guide. The kit also includes five of our most popular products to enhance your weight loss efforts and nourish your body with essential vitamins, minerals and nutrients.*

During Phase 1 you’ll start taking the NutriClean® 7-Day Cleansing System. This supplement uses nutrients, herbs and botanicals to mildly purge, detoxify and purify the digestive system. This is vital because priming your metabolism with a detox cleanse may increase weight loss. Another powerful product you will use is TLS® CORE Fat & Carb Inhibitor, which helps inhibit the amount of starchy carbohydrates being absorbed by the body. It also promotes a feeling of fullness, which will help keep you on track and away from unhealthy foods.*

For further support during Phase 1 of your Jump-Start we’ve included our Isotonix® Daily Essentials Packets, you can be sure that you’re giving your body the essential vitamins, minerals and nutrients it needs, thanks to four essential supplements – Isotonix OPC-3®, Isotonix Multivitamin, Isotonix Activated B-Complex and Isotonix Calcium Plus – in one, convenient serving to promote long-term health and optimal nutrition.*

To help round out your nutritional needs during Phase 2 of your Jump-Start, we’ve included Nutrition Shakes in the kit. The shakes provide additional protein to fuel your body and keep those hunger pangs at bay. For continued support during Phase 2, continue taking the Isotonix Daily Essentials Packets.*

When used as directed, these products provide a solid foundation for maximizing your metabolism and achieving successful weight loss. Refresh your system and reach your weight loss goals with this great new kit from the GoTrim System.*

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

TLS Weight Loss Solution is Now GoTrim

GoTrim is an educational program designed to help individuals achieve their weight management goals in a sustainable manner. It focuses on healthy metabolism and low-glycemic impact eating, guiding participants towards improved body composition. The program integrates science-based supplementation to help rebalance and support the body's metabolic processes. GoTrim is not just about weight loss; it is about adopting a healthier lifestyle, with an emphasis on making long-term changes rather than relying on temporary diets. The goal is to empower people to make healthier choices and develop habits that contribute to their overall well-being.

GoTrim Programs

FAQs

  1. Who should use the 30-Day Jump-Start Kit?
    Anyone who is looking for an easy-to-follow, cost-effective, all-inclusive kit that promotes optimal body composition and addresses the essentials of effective weight loss. Whether you need to tone up, lose weight or want to jumpstart a longer weight loss journey — the 30-Day Jump-Start Kit is for you.*

  2. How do I use the 30-Day Jump-Start Kit?
    During Phase 1, take the NutriClean® Cleansing System, Isotonix® Daily Essentials Packets and TLS® CORE Fat & Carb Inhibitor supplements. In Phase 2, use the Nutrition Shakes as snacks and continue taking the Isotonix Daily Essentials Packets and TLS CORE Fat & Carb Inhibitor supplements. For best results, use in conjunction with the 30-Day Jump-Start Guide. Follow the nutritional directive outlined in the Guide and take supplements as directed.

  3. How does TLS® CORE Fat & Carb Inhibitor support weight management?
    TLS CORE Fat & Carb Inhibitor enhances your weight loss efforts with its active ingredient, white kidney bean extract. White kidney bean extract inhibits the enzymes that normally breakdown starch into glucose within the small intestine. White kidney bean extract uses a calculated approach to affect the utilization of carbohydrates once they enter the body, helping to inhibit the absorption of carbohydrates. This gives you an advantage by minimizing the effects of surplus carbohydrates that are waiting to be converted into fat within the body.*

    TLS CORE Fat & Carb Inhibitor also contains Bitter melon (Momordica charantia) fruit extract, which is cultivated throughout South America as a food and for its health properties. Bitter melon is known for its health properties and its role in maintaining normal blood sugar levels. Charatin, one of several constituents in better melon, is believed to act as its primary mechanism to helping the body maintain normal blood sugar levels.* 

  4. How do I use NutriClean® 7-Day Cleansing System?
    You need to be sure that you are able to fully commit to the system for seven consecutive days. In the mornings, two hours after your first meal of the day, take two Release tablets (from the blister pack.) Also, drink 8 fluid ounces of the NutriClean Advanced Fiber Powder Drink Mix (mixing as directed). Throughout the day, be sure to drink plenty of water and other fluids (a minimum of 32 ounces, optimally 64 ounces per day). At bedtime, take the entire contents of one daily packet, which includes two Release tablets and two HepatoCleanse capsules. Repeat this cycle for seven consecutive days, taking the tablets/fiber/capsules at the same time each day.

  5. How do Nutrition Shakes assist with weight loss?
    Nutrition Shakes provide a source of quality protein to promote a feeling of fullness, helping you stay away from junk foods.

  6. Why do I need to take a multivitamin?
    A good quality vitamin and mineral supplement creates a sound micronutrient foundation to accompany a balanced diet. Vitamins and minerals help to support a healthy immune system, promote the conversion of food into energy, support a healthy cardiovascular system, support strong bones, promote mental clarity, help maintain normal metabolic functioning, promote healthy growth and repair of tissues, help maintain normal blood pressure and help maintain water and electrolyte balance in the body.*

  7. Why are Isotonix® supplements better than standard supplements?
    Isotonix formulas are more effective than standard supplement formulas because they offer efficient delivery of vitamins, minerals and nutrients into the bloodstream. The stomach has very little work to do because the pH and tonicity are carefully designed to allow the stomach to quickly release all the nutrients into the small intestine.*

  8. Do I have to exercise to see results? 
    In Phase 1 exercise is not recommended, but during Phase 2 exercise is essential. As with most weight loss supplements, these products are designed to be taken in conjunction with a healthy diet and exercise. The steady loss of body fat combined with a steady increase in muscle tissue, achieved through proper nutrition and exercise, is the proven method for achieving weight loss and fitness goals.


Scientific Studies

NutriClean® 7-Day Cleansing System

  • Agarwal K et al. Feasibility studies to control acute diarrhea in children by feeding fermented milk preparations Actimel and Indian Dahi. European Journal of Clinical Nutrition. 56(Supplement 4): S56-S59, 2002.
  • Arunachalam K et al. Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). European Journal of Clinical Nutrition. 54(3):263-7, 2000.
  • Brighenti F et al. Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers. European Journal of Clinical Nutrition. 53(9):726-733, 1999.
  • Cashman K. A prebiotic substance persistently enhances intestinal calcium absorption and increases bone mineralization in young adolescents. Nutrition Reviews. 64: 189-96, 2006.
  • Cetinkaya, A., et al. N-Acetylcysteine Ameliorates Methotrexate-Induced Oxidative Liver Damage in Rats. Medical Science Monitor. 12(8): 274-278, 2006.
  • Cummings J et al. A study of fructo oligosaccharides in the prevention of travellers' diarrhoea. Alimentary Pharmacology and Therapeutics. 15:1139-1145, 2001.
  • Cunningham-Rundles S et al. Probiotics and immune response. American Journal of Gastroenterology. 95(1 Suppl):S22-5, 2000.
  • Davidson M et al. Effects of dietary insulin in serum lipids in men and women with hypercholesterolaemia. Nutrition Research 3:503-17, 1998.
  • De Roos N et al. Effects of probiotic bacteria on diarrhea, lipid metabolism, and carcinogenesis: a review of papers published between 1988 and 1998. American Journal of Clinical Nutrition. 71(2):405-11, 2000.
  • Evans M et al. Glutamine prevents cytokine-induced apoptosis in human colonic epithelial cells. Journal of Nutrition. 133(10):3065-3071, 2003.
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  • Kren, V. and Walterova, D. Silybin and Silymarin--New Effects and Applications. Biomedical papers of the Medical Faculty of the University Palack

Nutrition Shake

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  • Burke, G, et al, The effect of whey protein supplementation with and without creatine monohydrate combined with resistance training on lean tissue mass and muscle strength. Int J Sport Nutr Exerc Metab 11, 3:349-64 (2001)
  • Meunier PJ. Calcium, vitamin D and vitamin K in the prevention of fractures due to osteoporosis. Osteoporos Int. 1999;9 Suppl 2:S48-52.
  • Miller ER 3rd, Appel LJ, Levander OA, Levine DM. The effect of antioxidant vitamin supplementation on traditional cardiovascular risk factors. J Cardiovasc Risk. 1997 Feb;4(1):19-24.
  • Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:283-303.
  • Nishi Y. Anemia and zinc deficiency in the athlete. J Am Coll Nutr. 1996 Aug;15(4):323-4.
  • Ohtani M, et al, Amino acid mixture improves training efficiency in athletes. J Nutr 136, 2:538S-543S (2006)
  • Rennie MJ, et al, Branched-chain amino acids as fuel and anabolic signals in human muscle. J Nutr 136, (1 Suppl): 264S-8S (2006)
  • Shimomura Y, et al, Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise. J Nutr 134, (6 Suppl): 1583S-1587S (2004)
  • Tipton KD, et al, Ingestion of casein and whey proteins result in muscle anabolism after resistance exercise. Med Sci Sports Exerc 36, 12:2073-81 (2004)
  • Tokunaga K and Matsuoka A, Effects of a [FOSHU] which contains indigestible dextrin as an effective ingredient on glucose and lipid metabolism," J Japanese Diabetes Society , 42:61-65, 1999.)
  • Wargovich MJ, Eng VWS, Newmark HL. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett. 1984; 23:253-258.
  • Weaver CM, Heaney RP. Calcium. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:141-155.
  • West KP Jr, Pokhrel RP, Katz J, et al. Efficacy of vitamin A in reducing preschool child mortality in Nepal. Lancet. 1991; 338:67-71.
  • West SG, Light KC, Hinderliter AL, et al. Potassium supplementation induces beneficial cardiovascular changes during rest and stress in salt sensitive individuals. Health Psychol. 1999; 18:229-240.
  • Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical triglyceride trials. JAMA. 1997; 277:1624-1632.
  • Wolf RL, Cauley JA, Baker CE, et al. Factors associated with calcium absorption efficiency in pre- and perimenopausal women. Am J Clin Nutr. 2000; 72:466-471.
  • Zemel MB, Shi H, Greer B, et al. Regulation of adiposity by dietary calcium. FASEB J. 2000; 14:1132-1138.

TLS® CORE Fat & Carb Inhibitor

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  • Bray, G. and York, D. Clinical review 90: Leptin and clinical medicine: a new piece in the puzzle of obesity. Journal of Clinical Endocrinology and Metabolism. 82(9):2771-6, 1997.
  • Cefalu, W. and Hu, F. Role of chromium in human health and in diabetes. Diabetes Care. 27: 2741- 2751, 2004.
  • Celleno, L., et al. A dietary supplement containing standardized Phaseolus vulgaris extract influences body composition of overweight men and women. International Journal of Medical Sciences. 4(1):45-52, 2007.
  • Di Pierro, F., et al. GreenSelect® Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Alternative Medicine Review. 14:154-160, 2009.
  • Flegal, K., et al. Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 303(3):235-241, 2010.
  • French, S. Effects of dietary fat and carbohydrate on appetite vary depending upon site and structure. British Journal of Nutrition. 93(Supplement 1): S23-S26, 2004.
  • Friedman, J. The function of leptin in nutrition, weight, and physiology. Nutrition Reviews. 60(10 Pt 2):S1-14; discussion S68-84, 85-7, 2002. Review.
  • Kaats, G., et al. A randomized, double-masked, placebo-controlled study of the effects of chromium picolinate supplementation on body composition: a replication and extension of a previous study. Current Therapeutic Research. 59(6): 379-387, 1998.
  • Kuate, D., et al. The use of LeptiCore in reducing fat gain and managing weight loss in patients with metabolic syndrome. Lipids in Health and Disease. 9: 1-7, 2010.
  • Martin, J., et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care. 29(8): 1826-1832, 2006.
  • Obiro, W., et al. The nutraceutical role of Phaseolus vulgaris alpha-amylase inhibitor. British Journal of Nutrition. 100: 1-12, 2008.
  • Pittler, M. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. American Journal of Clinical Nutrition. 79(4): 529-536, 2004.
  • Preuss, H. and Anderson, R. Chromium update: examining recent literature 1997-1998. Current Opinion in Clinical Nutrition and Metabolic Care. 1(6): 509-512, 1998.
  • Preuss H. Bean amylase inhibitor and other carbohydrate absorption blockers: effects on diabesity and general health. Journal of the American College of Nutrition. 28(3):266-76, 2009.
  • Qi, Y., et al. Adiponectin acts in the brain to decrease body weight. Nature Medicine. 10(5):524-9, 2004.
  • Rabinovitz, H., et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. International Journal of Vitamin and Nutrition Research. 74(3):178-82, 2004.
  • Sinha, M. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. Journal of Clinical Investigation. 98(6):1277-82, 1996.
  • Sparti, A., et al. Effect of diets high or low in unavailable and slowly digestible carbohydrates on the pattern of 24-h substrate oxidation and feeling of hunger in humans. The American Journal of Clinical Nutrition. 73: 1462-1468, 2000.
  • TalYeh, G., et al. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 26(4): 1277-1294, 2003.
  • Udani J., et al. Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean extract. Alternative Medicine Review. 9(1):63-9, 2004.
  • Udani, J and Singh B. Blocking carbohydrate absorption and weight loss: a clinical trial using a proprietary fractionated white bean extract. Alternative Therapies in Health and Medicine. 13(4):32-7, 2007.
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  • Zeman, M., et al. Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women. Neuro Endocrinology Letters. 30(3):387-95, 2009.

Isotonix® Daily Essentials Packets

Isotonix OPC-3®:

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  • Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
  • Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
  • Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
  • Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
  • Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
  • Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
  • Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
  • Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh
  • Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
  • Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
  • Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
  • Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
  • Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
  • Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
  • Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
  • Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
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  • Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
  • Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
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  • Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
  • Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999.
  • Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.
  • Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
  • Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
  • Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
  • Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
  • Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
  • Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
  • Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
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  • Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
  • Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
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  • Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency. Phytother Res 16:S1-5, 2002.
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  • Qureshi, A, et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 30:1171-77, 1995.
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  • Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-9, 2003.
  • Wilson D et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 24(8):1115-9, 2010.
  • Lau B et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 41(8):825-32, 2004.
  • Choi YH, Yan GH. Pycnogenol® inhibits immunoglobulin E-mediated allergic response in mast cells. Phytother Res 23: 1691-1695, 2009.
  • Sharma SC, Sharma S, Gulati OP. Pycnogenol® inhibits the release of histamine from mast cells. Phytother Res, 17: 66-69, 2003.
  • Hosseini S, Pishnamazi S, Sadrzadeh MH, Farid F, Farid R, Watson RR. Pycnogenol® in the management of asthma. J Med Food 4: 201-209, 2001.

Isotonix® Multivitamin

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  • Wahl R, Pilz-Mittenburg KW, Heer W, Kallee E. Iodine content in diet and excretion of iodine in urine. Z Ernahrungswiss. 1995 Dec;34(4):269-76.
  • Walker LS, Bemben MG, Bemben DA, Knehans AW. Chromium picolinate effects on body composition and muscular performance in wrestlers. Med Sci Sports Exerc. 1998 Dec;30(12):1730-7.
  • Wang Y, Mackenzie B, Tsukaguchi H, et al. Human vitamin C (L-ascorbic acid) transporter SVCT1. Biochem Biophys Res Commun. 2000; 267:488-494.
  • Wargovich MJ, Eng VWS, Newmark HL. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett. 1984; 23:253-258.
  • Weaver CM, Heaney RP. Calcium. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:141-155.
  • West KP Jr, Pokhrel RP, Katz J, et al. Efficacy of vitamin A in reducing preschool child mortality in Nepal. Lancet. 1991; 338:67-71.
  • West SG, Light KC, Hinderliter AL, et al. Potassium supplementation induces beneficial cardiovascular changes during rest and stress in salt sensitive individuals. Health Psychol. 1999; 18:229-240.
  • Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical triglyceride trials. JAMA. 1997; 277:1624-1632.
  • Wolf RL, Cauley JA, Baker CE, et al. Factors associated with calcium absorption efficiency in pre- and perimenopausal women. Am J Clin Nutr. 2000; 72:466-471.
  • Young DB, Lin H, McCabe RD. Potassium's cardiovascular protective mechanisms. Am J Physiol. 1995; 268:R825-R837.
  • Young DB, Ma G. Vascular protective effects of potassium. Semin Nephrol. 1999; 19:477-486.
  • Zemel MB, Shi H, Greer B, et al. Regulation of adiposity by dietary calcium. FASEB J. 2000; 14:1132-1138.
  • Zhou B, Wang T, Sun G, Guan P, Wu JM. A case-control study of the relationship between dietary factors and risk of lung cancer in women of Shenyang, China. Oncol Rep. 1999 Jan-Feb;6(1):139-43.
  • Zhou MS, Nishida Y, Yoneyama H, et al. Potassium supplementation increases sodium excretion in hypertensive Dahl rats. Clin Exp Hypertens.

Isotonix® Activated B-Complex

  • Benton D., et al. Thiamine supplementation for mood and cognitive functioning. Psychopharmacology. 129(1):66-71, 1997.
  • Benton, D., et al. The effects of nutrients on mood. Public Health Nutr. 2(3A):403-409, 1999.
  • Bhagavan, H. N., et al. The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children. Pediatrics. 55(3):437-441, 1975.
  • Bronstrup A, Hages M, Prinz-Langenohl R, Pietrzik K. Effects of folic acid and
  • Bryan, J., et al. Associations between dietary intake of folate and vitamins B-12 and B-6 and self-reported cognitive function and psychological well-being in Australian men and women in midlife. J Nutr Health Aging. 8(4):226-232, 2004.
  • Bryan, J., et al. Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages. Journal of Nutrition. 132(6):1345-1356, 2002.
  • combinations of folic acid and vitamin B12 on plasma homocysteine concentrations in healthy young women. Am J Clin Nutr 68:1104-10, 1998.
  • Coppen, A., et al. Plasma folate and affective morbidity during long-term lithium therapy. Br J Psychiatry. 141:87-89, 1982.
  • Cummings, P. M., et al. Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease. J Am Coll Cardiol. 36:758-765, 2000.
  • Dharmarajan, T. S., et al. Vitamin B12 deficiency. Recognizing subtle symptoms in older adults. Geriatrics. 58(3):30-34, 2003.
  • Doshi, S. N., et al. Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation. 105(1):22-26, 2002.
  • Duthie, S. J., et al. Homocysteine, B vitamin status, and cognitive function in the elderly. American Journal of Clinical Nutrition. 75(5):908-913, 2002.
  • Friso, S., et al. Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk. Am J Clin Nutr. 79(6):992-998, 2004.
  • Grant, J. E., et al. Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome. J Am Diet Assoc. 96(4):383-386, 1996.
  • Hartvig, P., et al. Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with position emission tomography. Neural Trans. 102:91-97, 1995.
  • Heap, L. C., et al. Vitamin B status in patients with chronic fatigue syndrome. J R Soc Med. 92(4):183-185, 1999.
  • Heseker, H., et al. Psychological disorders as early symptoms of a mild-to-moderate vitamin deficiency. Ann N Y Acad Sci. 669:352-357, 1992.
  • Jacobson, W., et al. Serum folate and chronic fatigue syndrome. Neurology. 43:2645-2647, 1993.
  • Kelly, G. S. Nutritional and botanical interventions to assist with the adaptation to stress. Alternative Medicine Review.4(4):249-265, 1999.
  • Litoff, D., et al. Effects of pantothenic acid supplementation on human exercise. Med Sci Sport Exercise., 17(Supplement):287, 1985.
  • Osada, K., et al. Experimental study of fatigue provoked by biotin deficiency in mice. Int J Vitam Nutr Res. 74(5):334-340, 2004.
  • Quadri, P., et al. Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr. 80(1):114-122, 2004.
  • Riggs, K. M., et al. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. American Journal of Clinical Nutrition. 63(3):306-314, 1996.
  • Van den Berg M., et al. Combined vitamin B-6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia. Journal Vascular Surgery. 20(6):933-940, 1994.
  • van Oort FV, Melse-Boonstra A, Brouwer IA, et al. Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. 77:1318-23, 2003.
  • Vargiu, R., et al. Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q(10), nicotinamide, riboflavin and pantothenic acid in the rat. Physiol Behav. 76(2):257-63, 2002.
  • Wald DS, Bishop L, Wald NJ, et al. Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med 61:695-700, 2001.
  • Werbach, M. R. Nutritional strategies for treating chronic fatigue syndrome. Alternative Medicine Review. 5(2):93-108, 2000.
  • Woo, K. S., et al. Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation. American Journal of Medicine. 112(7):535-539, 2002.

Isotonix® Calcium Plus:

  • Allender PS, Cutler JA, Follman D, et al. Dietary calcium and blood pressure: meta—analysis of randomized clinical trials. Ann Intern Med. 1996; 124:825-831.
  • Altura BM, Altura BT. Role of magnesium and calcium in alcohol-induced hypertension and strokes as probed by in vivo television microscopy, digital image microscopy, optical spectroscopy, 31P-NMR, spectroscopy and a unique magnesium ion-selective electrode. Alcohol Clin Exp Res. 1994; 18:1057-1068.
  • Baly DL, Schneiderman JS, Garcia-Welsh AL. Effect of manganese deficiency on insulin binding, glucose transport and metabolism in rat adipocytes. J Nutr. 1990; 120:1075-1079.
  • Baron JA, Beach M, Mandel JS, et al. Calcium supplements for the prevention of colorectal adenomas. N Engl J Med 1999;340:101-107.
  • Baron JA, Tosteson TD, Wargovich MJ, et al. Calcium supplementation and rectal mucosal proliferation: a randomized controlled trial. J Natl Cancer Inst 1995;87:1303-1307.
  • Baxter GF, Sumeray MS, Walker JM. Infant size and magnesium: insights into LIMIT-2 and ISIS-4 from experimental studies. Lancet. 1996; 348:1424-1426.
  • Beattie JH, Peace HS. The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. Br J Nutr. 1993 May;69(3):871-84.
  • Bell L, Halstenson CE, Halstenson CJ, et al. Cholesterol-lowering effects of calcium carbonate in patients with mild to moderate hypercholesterolemia. Arch Intern Med. 1992; 152:2441-2444.
  • Bostick RM, Kushi LH, Wu Y, et al. Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol 1999;149:151-160.
  • Britton J, Pavord I, Richards K, et al. Dietary magnesium, lung function, wheezing, and airway hyper-reactivity in a random adult population sample. Lancet. 1994; 344:357-362.
  • Buckley LM, Leib ES, Cartularo KS, et al. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. Ann Intern Med. 1996; 125:961-968.
  • Casscells W. Magnesium and myocardial infarction. Lancet. 1994; 343:807-809.
  • Christiansen CW, Rieder MA, Silverstein EL, Gencheff NE. Magnesium sulfate reduces myocardial infarct size when administered before but not after coronary reperfusion in a canine model. Circulation. 1995; 92:2617-2621.
  • Christin Marandino, Vegetarian Times, August 1998
  • Curhan GC, Willett WC, Speizer FE, et al. Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk of kidney stones in women. Ann Intern Med. 1997; 126:497-504.
  • Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density on men and women 65 years of age and older. N Engl J Med. 1997; 337:670-676.
  • de Lourdes Lima M, Cruz T, Carreiro Pousada J, et al. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care. 1998; 21:682-686.
  • Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press; 1997.
  • Durlach J, Durlach V, Bac P, et al. Magnesium and therapeutics. Magnes Res. 1994; 7:313-328.
  • Elisaf M, Merkouropoulos M, Tsianos EV. Siamopoulos KC. Pathogenetic mechanisms of hypomagnesemia in alcoholic patients. J Trace Elem Med Biol. 1995; 9:210-214.
  • Facchinetti F, Borella P, Sances G, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol. 1991; 78:177-181.
  • Garland CF, Garland FC, Gorham ED. Calcium and vitamin D. Their potential roles in colon and breast cancer prevention. Ann NY Acad Sci. 1999; 889:107-119.
  • Gong H, Amemiya T. Optic nerve changes in manganese-deficient rats. Exp Eye Res. 1999; 68:313-320.
  • Gullestad L, Dolva LO, Soyland E, et al. Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics. Alcohol Clin Exp Res. 1992; 16:986-990.
  • Health & Medicine. (Statistical Data Included) American Fitness, July, 1999 Tannen RL. Effects of potassium on blood pressure control. Ann Intern Med. 1983; 98(part 2):773-780.
  • Heaney RP. Calcium, dairy products and osteoporosis. J Am Coll Nutr. 2000; 19(2 Suppl):83S-99S.
  • Hussain S, Ali SF. Manganese scavenges superoxide and hydroxyl radicals: an in vitro study in rats. Neuroscience Letters. 1999; 261:21-24.
  • ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulfate in 58,050 patients with suspected acute myocardial infarction. Lancet. 1995; 345:669-685.
  • Jorde R, Sundsfjord J, Haug E, et al. Relation between low calcium intake, parathyroid hormone, and blood pressure. Hypertension 2000;35:1154-1159.
  • Kao WHL, Folsom AR, Nieto J, et al. Serum and dietary magnesium and the risk for type 2 diabetes mellitus (editorial). Arch. Int Med. 1999; 159:2151-2159.
  • Keen CL, Ensunsa JL, Watson MH, et al. Nutritional aspects of manganese from experimental studies. Neurotoxicol. 1999; 20:213-223.
  • Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet. 1995; 346:270-274.
  • Lim R, Herzog WR. Magnesium for cardiac patients: is it a valuable treatment supplement? Contemp Int Med. 1998; 10:6-9.
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  • Lucas MJ, Leveno KJ, Cunningham FG. A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia. N Engl J Med. 1995; 333:201-205.
  • Martini LA. Magnesium supplementation and bone turnover. Nutr Rev. 1999; 57:227-229.
  • Mauskop A, Altura BM. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci. 1998; 5:24-27.
  • Naghii MR, Wall PM, Samman S. The boron content of selected foods and the estimation of its daily intake among free-living subjects. J Am Coll Nutr. 1996 Dec;15(6):614-9.
  • Newnham RE. Essentiality of boron for healthy bones and joints. Environ Health Perspect. 1994;102:83-85
  • Nielsen FH. Studies on the relationship between boron and magnesium which possibly affects the formation and maintenance of bones. Magnes Trace Elem. 1990;9:61-69
  • Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:283-303.
  • Oginni LM, Sharp CA, Worsfold M, et al. Healing of rickets after calcium supplementation. Lancet. 1999; 353:296-297.
  • Orchard TJ. Magnesium and type 2 diabetes mellitus (editorial). Arch Int Med. 1999; 159:2119-2120.
  • Paolisso G, Sgamabato S, Pizza G, et al. Improved insulin response and action by chronic magnesium administration in aged NIDDM. Diabetes Care. 1989; 12:265-269.
  • Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia. 1996; 16:257-263.
  • Penland J.G. The importance of boron nutrition for brain and psychological function. Biol Trace Elem Res. 1998; 66:299-317.
  • Recker RR. Calcium absorption and achlorhydria. N Engl J Med. 1985; 313:70-73. Reid IR, Ames RW, Evans MC, et al. Effect of calcium supplementation on bone loss in postmenopausal women. N Engl J Med. 1993; 328:460-464.
  • Rivlin RS. Magnesium deficiency and alcohol intake: mechanisms, clinical significance and possible relation to cancer development (a review). J Am Coll Nutr. 1994; 13:416-423.
  • Roberts JM. Magnesium for preeclampsia and eclampsia. N Engl J Med. 1995; 333:250-251.

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